I've been running CentOS 5.3, 5.4, 5.5, and now 5.6 on Hyper-V. It has always been possible to install and run CentOS on Hyper-V, but until now, it was not "supported" (meaning Microsoft Product Support Services would refuse to answer any questions, post any KB articles, or otherwise facilitate smooth installation and operation of CentOS on Hyper-V).
In tangible terms, this meant that there was no ready-to-use RPM available for "Integration Components" (Hyper-V's equivalent of "VMware Tools"); it meant that there was no guidance explaining that you must modify the NIC config immediately after creating a new VM because Hyper-V's GUI "wizard" always adds a "Network Adapter" but you need it to be the "Legacy Network Adapter" instead; it meant that if you wanted to run xorg, you had to hunt for Satori (mouse support which isn't included with the Integration Components because it is maintained by Citrix for Xen). None of this stuff would be challenging if you were well-versed in both CentOS and Hyper-V. However, most people tend to learn toward one side.
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