I have posted my review of the Microsoft Natural Wireless Laser Mouse 6000. Here is an excerpt:
The design is really odd at first. The mouse is designed so you do not have to turn your hand and wrist, and just keep in your natural position. I think this design is one to get used to, like the natural keyboard designs. When I used the mouse it felt like my hand was too high up and felt like I was holding something in my hand rather than naturally using the mouse. I can see, though, how this mouse can help you in the long run because you aren't turning your wrist. But - this mouse will definitely take some getting used to. Clicking the two left side buttons was very awkward and almost impossible using my thumb and finger. I have medium sized hands and my hand rested on the mouse fine, but I could see if you had smaller hands you might feel awkward.
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